Anti-cell adhesion characteristics of nanotextured surface > Detailed Program

Code No.	BM-P37
Name	Prof. Byeong Hee Kim
Affiliation	Kangwon National University
Title	Anti-cell adhesion characteristics of nanotextured surface
File of Abstract

Co-author-1	Prefix	Mr.
	Country	Korea
	First name	Eui Don
	Last name	Han
	Affiliation	Kangwon national University
	Department	Mechatronics engineering
	E-mail	luvkhy@kangwon.ac.kr
	Cell phone	8210-2368-2614

Co-author-2	Prefix	Prof.
	Country	Korea
	First name	Young Ho
	Last name	Seo
	Affiliation	Kangwon National University
	Department	Mechatronics engineering
	E-mail	mems@kangwon.ac.kr
	Cell phone	+82-10-6408-0430

Contents
Temporary implantable biomedical devices such as intramedullary nails and stent need to inhibit cell adhesion and proliferation in contrast with permanent implantable medical devices. Various studies were carried out for inhibition of endothelialization, however, most methods needed complicated processes and were not permanent. In this paper, a permanent anti-cell adhesion surface was presented using nanotexturing method of nano-imprinting process. Cell adhesion characteristics on nanotextured polymer layer was compared to that on the planar polymer surface and cell culture dish. NIH3T3 fibroblast cell was cultured each substrate and investigated. Fig 1. shows cultured cells after 56 hours on each substrate. Contrastively, cells on the nanotextured polymer surface couldn’t adhered actively compared to another substrates during the whole culture time. Fig 3. represents the ratio of fibroblast cell covered area to cultured area for each substrate according to cell culture time. Cell adhesion area of nanotextured surface was less than half of that in cell culture dish and planar polymer substrate. According to results, anti-cell adhesion characteristics could be permanently assigned through surface nanotexturing method without any chemical treatment.

Contents

Temporary implantable biomedical devices such as intramedullary nails and stent need to inhibit cell adhesion and proliferation in contrast with permanent implantable medical devices. Various studies were carried out for inhibition of endothelialization, however, most methods needed complicated processes and were not permanent. In this paper, a permanent anti-cell adhesion surface was presented using nanotexturing method of nano-imprinting process. Cell adhesion characteristics on nanotextured polymer layer was compared to that on the planar polymer surface and cell culture dish. NIH3T3 fibroblast cell was cultured each substrate and investigated. Fig 1. shows cultured cells after 56 hours on each substrate. Contrastively, cells on the nanotextured polymer surface couldn’t adhered actively compared to another substrates during the whole culture time. Fig 3. represents the ratio of fibroblast cell covered area to cultured area for each substrate according to cell culture time. Cell adhesion area of nanotextured surface was less than half of that in cell culture dish and planar polymer substrate. According to results, anti-cell adhesion characteristics could be permanently assigned through surface nanotexturing method without any chemical treatment.

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NANOPIA2015

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