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Detailed Program (Poster)

The 2nd International Conference & Exhibition for Nanopia

Code No. BM-P17
Name Mr. Yong Cheol Shin
Affiliation Pusan National University
Title Graphene oxide-decorated PLGA/RGD peptide nanofiber sheets for enhanced myogenesis
File of Abstract
Co-author-1PrefixMr.
CountryKorea
First nameJong Ho
Last nameLee
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailpignunssob@naver.com
Cell phone82-1048756992
Co-author-2PrefixMs.
CountryKorea
First nameMin Jeong
Last nameKim
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailkdh6253@nate.com
Cell phone82-1040031215
Co-author-3PrefixMr.
CountryKorea
First nameJi Hoon
Last namePark
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailsmilemippy@gmail.com
Cell phone82-1065063955
Co-author-4PrefixMr.
CountryKorea
First nameSung Eun
Last nameKim
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mail01048470363@naver.com
Cell phone82-1048470363
Co-author-5PrefixMr.
CountryKorea
First nameJin Su
Last nameKim
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailwlstn5756@naver.com
Cell phone82-1092305756
Co-author-6PrefixProf.
CountryKorea
First nameJin-Woo
Last nameOh
AffiliationPusan National University
DepartmentDepartment of Nanoenergy Engineering
E-mailojw@pusan.ac.kr
Cell phone82-519307725
Co-author-7PrefixProf.
CountryKorea
First nameSuck Won
Last nameHong
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailswhong@pusan.ac.kr
Cell phone82-519307725
Co-author-8PrefixProf.
CountryKorea
First nameYu Suk
Last nameChoi
AffiliationUniversity of Western Australia
DepartmentSchool of Anatomy, Physiology, and Human Biology
E-mailyusuk.choi@uwa.edu.au
Cell phone82-519307725
Co-author-9PrefixProf.
CountryKorea
First nameDong-Wook
Last nameHan
AffiliationPusan National University
DepartmentDepartment of Cogno-Mechatronics Engineering
E-mailnanohan@pusan.ac.kr
Cell phone82-1073920237
Contents
Herein, we fabricated graphene oxide (GO)-decorated poly(lactic-co-glycolic acid, PLGA)/RGD peptide (GO-PLGA/RGD) nanofiber sheets by electrospinning. The physicochemical properties of GO-PLGA/RGD sheets were investigated, and the enhanced myogenesis on the sheets was examined. The GO-PLGA/RGD sheets had a three-dimensional porous structure, indicating that their structure was closely similar to that of the natural extracellular matrix. In addition, Fourier transform infrared and Raman spectra revealed that the GO and RGD peptide were homogeneously distributed in the sheets. The cellular behaviors of skeletal muscle and vascular smooth muscle cells were evaluated by cell counting kit-8 assay and immunofluorescence staining. Our results showed that the initial adhesion and proliferation of the cells were promoted on the GO-PLGA/RGD sheets. Moreover, the myogenesis of myoblasts was substantially enhanced on the GO-PLGA/RGD sheets. These results indicated that the GO-PLGA/RGD nanofiber sheets had suitable physicochemical properties for biomimetic scaffolds and can promote the cellular behaviors. In conclusion, it is suggested that the GO-PLGA/RGD nanofiber sheets can be effectively employed as biomimetic scaffolds enhancing the myogenesis and tissue regeneration.

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