1H MR Spectroscopy of 2-Hydroxyglutarate

Time 2015-11-13 14:30~15:00 Place Room 605+606
Code No. BM-I16 Session Chair
Name Prof. Chang Ho Choi
Affiliation Univ of Texas Southwestern Medical Center
Title 1H MR Spectroscopy of 2-Hydroxyglutarate
CountryUnited State of America
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The discovery of the production of 2-hydroxyglutarate (2HG) in gliomas with mutations in isocitrate dehydrogenase (IDH) 1 and 2 has created great excitement among basic scientists and neuro-oncologists. Although the role of 2HG is well established for diagnosis and prognosis, how it can be used for improving patient care is largely unknown. Here we present in-vivo 1H MR spectroscopy data from >100 glioma patients and discuss the clinical utility of 2HG. The data indicate that 2HG is a sensitive biomarker for monitoring tumor stableness, progression, and response to treatment in IDH-mutated gliomas. Noninvasive analysis of 2HG by MRS may have the great potential for developing methods for therapeutic benefit.